Francois Jenck: search on Z-Library

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1

Biomedical Application of Orexin/Hypocretin Receptor Ligands in Neuroscience

Boss, Christoph, Brisbare-Roch, Catherine, Jenck, Francois

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 280 KB

english, 2009

2

Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant

Hendrik Dietrich, François Jenck

Journal:

Psychopharmacology

Year:

2010

Language:

english

File:

PDF, 329 KB

english, 2010

3

Discovery and Characterization of ACT-335827, an Orally Available, Brain Penetrant Orexin Receptor Type 1 Selective Antagonist

Steiner, Michel A., Gatfield, John, Brisbare-Roch, Catherine, Dietrich, Hendrik, Treiber, Alexander, Jenck, Francois, Boss, Christoph

Journal:

Year:

2013

Language:

english

File:

PDF, 342 KB

english, 2013

4

Structure-Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT-462206: a Potent, Brain-Penetrant Dual Orexin 1/Orexin 2 Receptor Antagonist

Boss, Christoph, Roch-Brisbare, Catherine, Steiner, Michel A., Treiber, Alexander, Dietrich, Hendrik, Jenck, Francois, von Raumer, Markus, Sifferlen, Thierry, Brotschi, Christine, Heidmann, Bibia, Wil

Journal:

Year:

2014

Language:

english

File:

PDF, 816 KB

english, 2014

5

The brain orexin system and almorexant in fear-conditioned startle reactions in the rat

Michel A. Steiner, Hugues Lecourt, Francois Jenck

Journal:

Psychopharmacology

Year:

2012

Language:

english

File:

PDF, 297 KB

english, 2012

6

High-Affinity, Non-Peptide Agonists for the ORL1 (Orphanin FQ/Nociceptin) Receptor

Röver, Stephan, Adam, Geo, Cesura, Andrea M., Galley, Guido, Jenck, François, Monsma,, Frederick J., Wichmann, Jürgen, Dautzenberg, Frank M.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 124 KB

english, 2000

7

Pharmacological characterization of benzodiazepine receptor ligands with intrinsic efficacies ranging from high to zero

James R. Martin, Peter Schoch, François Jenck, Jean-Luc Moreau, Willy E. Haefely

Journal:

Psychopharmacology

Year:

1993

Language:

english

File:

PDF, 1.14 MB

english, 1993

8

Opposite control mediated by central 5-HT1A and non-5-HT1A (5-HT1B or 5-HT1C) receptors on periaqueductal gray aversion

François Jenck, Chris L. Broekkamp, Anton M.L. Van Delft

Journal:

European Journal of Pharmacology

Year:

1989

Language:

english

File:

PDF, 227 KB

english, 1989

9

Orexin Receptor Antagonists: A New Concept In CNS Disorders?

John Gatfield, Catherine Brisbare-Roch, Francois Jenck, Christoph Boss

Journal:

Year:

2010

Language:

english

File:

PDF, 913 KB

english, 2010

10

5-HT1Creceptors in the serotonergic control of periaqueductal gray induced aversion in rats

François Jenck, Chris L. E. Broekkamp, Anton M. L. Delft

Journal:

Psychopharmacology

Year:

1990

Language:

english

File:

PDF, 718 KB

english, 1990

11

Drug-induced potentiation of prepulse inhibition of acoustic startle reflex in mice: a model for detecting antipsychotic activity?

Abdel-Mouttalib Ouagazzal, François Jenck, Jean-Luc Moreau

Journal:

Psychopharmacology

Year:

2001

Language:

english

File:

PDF, 137 KB

english, 2001

12

Behavioral effects of CCKB receptor ligands in a validated simulation of panic anxiety in rats

François Jenck, James R. Martin, Jean-Luc Moreau

Journal:

European Neuropsychopharmacology

Year:

1996

Language:

english

File:

PDF, 843 KB

english, 1996

13

Aniracetam improves radial maze performance in rats

Martin, James R., Cumin, Rudolf, Aschwanden, Werner, Moreau, Jean-Luc, Jenck, François, Haefely, Willy E.

Journal:

Year:

1992

File:

PDF, 172 KB

1992

14

Effects of Ro 64-6198 in nociceptin/orphanin FQ-sensitive isolated tissues

Daniela Rizzi, Raffaella Bigoni, Anna Rizzi, Francois Jenck, Juergen Wichmann, Remo Guerrini, Domenico Regoli, Girolamo Calo'

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2001

Language:

english

File:

PDF, 135 KB

english, 2001

15

Targeted Disruption of the Orphanin FQ/Nociceptin Gene Increases Stress Susceptibility and Impairs Stress Adaptation in Mice

Anja Koster, Alexandra Montkowski, Stefan Schulz, Eva-Maria Stube, Kristina Knaudt, Francois Jenck, Jean-Luc Moreau, Hans-Peter Nothacker, Olivier Civelli and Rainer K. Reinscheid

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.69 MB

english, 1999

16

Discovery and optimisation of 1-acyl-2-benzylpyrrolidines as potent dual orexin receptor antagonists

Williams, Jodi T., Gatfield, John, Roch, Catherine, Treiber, Alexander, Jenck, Francois, Bolli, Martin H., Brotschi, Christine, Sifferlen, Thierry, Heidmann, Bibia, Boss, Christoph

Journal:

Year:

2015

Language:

english

File:

PDF, 750 KB

english, 2015

17

Functional Consequences of Reduction in NMDA Receptor Glycine Affinity in Mice Carrying Targeted Point Mutations in the Glycine Binding Site

Kew, James N. C., Koester, Anja, Moreau, Jean-Luc, Jenck, Francois, Ouagazzal, Abdel-Mouttalib, Mutel, Vincent, Richards, J. Grayson, Trube, Gerhard, Fischer, Guenther, Montkowski, Alexandra, Hundt, W

Journal:

Journal of Neuroscience

Year:

2000

File:

PDF, 732 KB

2000

18

Syntheses of O-Methylasparvenone-Derived Serotonin-Receptor Antagonists

Michael Bös, Heinz Stadler, Jürgen Wichmann, François Jenck, James R. Martin, Jean-Luc Moreau, Andrew J. Sleight

Journal:

Helvetica Chimica Acta

Year:

1998

Language:

english

File:

PDF, 906 KB

english, 1998

19

N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists

Hamed Aissaoui, Ralf Koberstein, Cornelia Zumbrunn, John Gatfield, Catherine Brisbare-Roch, Francois Jenck, Alexander Treiber, Christoph Boss

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 203 KB

english, 2008

20

Some critical determinants of the behaviour of rats in the elevated plus-maze

Guy Griebel, Jean-Luc Moreau, François Jenck, James R. Martin, René Misslin

Journal:

Behavioural Processes

Year:

1993

Language:

english

File:

PDF, 727 KB

english, 1993

21

Aniracetam reverses memory impairment in rats

James R. Martin, Jean-Luc Moreau, François Jenck

Journal:

Pharmacological Research

Year:

1995

Language:

english

File:

PDF, 423 KB

english, 1995

22

Structure–activity relationship studies and sleep-promoting activity of novel 1-chloro-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 2

Sifferlen, Thierry, Koberstein, Ralf, Cottreel, Emmanuelle, Boller, Amandine, Weller, Thomas, Gatfield, John, Brisbare-Roch, Catherine, Jenck, Francois, Boss, Christoph

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 925 KB

english, 2013

23

A neuropharmacological study of the periventricular neural substrate involved in flight

Pierre Schmitt, Pascal Carrive, Georges Di Scala, François Jenck, Marcus Brandao, Abdallah Bagri, Jean-Luc Moreau, Guy Sandner

Journal:

Behavioural Brain Research

Year:

1986

Language:

english

File:

PDF, 845 KB

english, 1986

24

Novel Agonists of 5HT 2C Receptors. Synthesis and Biological Evaluation of Substituted 2-(Indol-1-yl)-1-methylethylamines and 2-(Indeno[1,2- b ]pyrrol-1-yl)-1-methylethylamines. Improved Therapeutics for Obsessive Compulsive Disorder †

Bös, Michael, Jenck, François, Martin, James R., Moreau, Jean-Luc, Sleight, Andrew J., Wichmann, Jürgen, Widmer, Ulrich

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 180 KB

english, 1997

25

ChemInform Abstract: Synthesis of (1S,3aS)-8- (2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro [4.5]decan-4-one, a Potent and Selective Orphanin FQ (OFQ) Receptor Agonist with Anxiolytic-Like Properties.

Juergen Wichmann, Geo Adam, Stephan Roever, Michael Hennig, Michelangelo Scalone, Andrea M. Cesura, Frank M. Dautzenberg, Francois Jenck

Journal:

Year:

2000

File:

PDF, 39 KB

2000

26

8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as orphanin FQ receptor agonists

Jürgen Wichmann, Geo Adam, Stephan Röver, Andrea M. Cesura, Frank M. Dautzenberg, François Jenck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 272 KB

english, 1999

27

Effects of pimozide and naloxone on latency for hypothalamically induced eating

Francois Jenck, Alain Gratton, Roy A. Wise

Journal:

Year:

1986

Language:

english

File:

PDF, 704 KB

english, 1986

28

Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2

Sifferlen, Thierry, Boller, Amandine, Chardonneau, Audrey, Cottreel, Emmanuelle, Gatfield, John, Treiber, Alexander, Roch, Catherine, Jenck, Francois, Aissaoui, Hamed, Williams, Jodi T., Brotschi, Chr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 904 KB

english, 2015

29

Novel pyrazolo-tetrahydropyridines as potent orexin receptor antagonists

Thierry Sifferlen, Christoph Boss, Emmanuelle Cottreel, Ralf Koberstein, Markus Gude, Hamed Aissaoui, Thomas Weller, John Gatfield, Catherine Brisbare-Roch, Francois Jenck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 504 KB

english, 2010

30

Effects of serotonin receptor antagonists on PAG stimulation induced aversion: different contributions of 5HT1, 5HT2and 5HT3receptors

François Jenck, Chris L. E. Broekkamp, Anton M. L. Delft

Journal:

Psychopharmacology

Year:

1989

Language:

english

File:

PDF, 895 KB

english, 1989

31

Reply to 'Promotion of sleep by targeting the orexin system in rats, dogs and humans'

Jenck, Francois, Brisbare-Roch, Catherine, Scherz, Michael, Flores, Susan, Koberstein, Ralf, Nayler, Oliver, Dingemanse, Jasper, Clozel, Martine

Journal:

Nature Medicine

Year:

2007

Language:

english

File:

PDF, 73 KB

english, 2007

32

Opioid receptor subtypes associated with ventral tegmental facilitation of lateral hypothalamic brain stimulation reward

François Jenck, Alain Gratton, Roy A. Wise

Journal:

Year:

1987

Language:

english

File:

PDF, 389 KB

english, 1987

33

The effect of antidepressants on aversive periaqueductal gray stimulation in rats

François Jenck, Chris L.E. Broekkamp, Anton M.L. Van Delft

Journal:

European Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 266 KB

english, 1990

34

Morphine injected into the periaqueductal gray attenuates brain stimulation-induced effects: An intensity discrimination study

Francois Jenck, Pierre Schmitt, Pierre Karli

Journal:

Year:

1986

Language:

english

File:

PDF, 871 KB

english, 1986

35

The dual orexin receptor antagonist almorexant, alone and in combination with morphine, cocaine and amphetamine, on conditioned place preference and locomotor sensitization in the rat

Steiner, Michel Alexander, Lecourt, Hugues, Jenck, François

Journal:

The International Journal of Neuropsychopharmacology

Year:

2013

Language:

english

File:

PDF, 291 KB

english, 2013

36

The use of physiology-based PK and PD modeling in the discovery of the dual orexin receptor antagonist ACT-541468

Treiber, Alexander, de Kanter, Ruben, Roch, Catherine, Gatfield, John, Boss, Christoph, von Raumer, Markus, Schindelholz, Benno, Muehlan, Clemens, van Gerven, Joop, Jenck, Francois

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2017

Language:

english

File:

PDF, 1.14 MB

english, 2017

37

Opioid receptor subtypes associated with ventral tegmental facilitation and periaqueductal gray inhibition of feeding

François Jenck, Rémi Quirion, Roy A. Wise

Journal:

Year:

1987

Language:

english

File:

PDF, 458 KB

english, 1987

38

Contraversive circling induced by ventral tegmental microinjections of moderate doses of morphine and [d-Pen2,d-Pen5]enkephalin

Francois Jenck, Michael Bozarth, Roy A. Wise

Journal:

Year:

1988

Language:

english

File:

PDF, 439 KB

english, 1988

39

Novel Hexahydrospiro[piperidine-4,1‘-pyrrolo[3,4- c ]pyrroles]: Highly Selective Small-Molecule Nociceptin/Orphanin FQ Receptor Agonists

Kolczewski, Sabine, Adam, Geo, Cesura, Andrea M., Jenck, François, Hennig, Michael, Oberhauser, Thomas, Poli, Sonia M., Rössler, Felix, Röver, Stephan, Wichmann, Jürgen, Dautzenberg, Frank M.

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 169 KB

english, 2003

40

ChemInform Abstract: High-Affinity, Nonpeptide Agonists for the ORL1 (Orphanin FQ/Nociceptin) Receptor.

Stephan Roever, Geo Adam, Andrea M. Cesura, Guido Galley, Francois Jenck, Frederick J. Monsma Jr., Juergen Wichmann, Frank M. Dautzenberg

Journal:

Year:

2000

File:

PDF, 30 KB

2000

41

Sarmazenil-Precipitated Withdrawal: A Reliable Method for Assessing Dependence Liability of Benzodiazepine Receptor Ligands

James R Martin, Jean-Luc Moreau, François Jenck, Lorenzo Pieri

Journal:

Pharmacology Biochemistry and Behavior

Year:

1998

Language:

english

File:

PDF, 105 KB

english, 1998

42

Involvement of 5-HT1C-receptors in drug-induced penile erections in rats

Hemmie H. G. Berendsen, François Jenck, Chris L. E. Broekkamp

Journal:

Psychopharmacology

Year:

1990

Language:

english

File:

PDF, 651 KB

english, 1990

43

Favoured genetic background for testing anxiolytics in the fear-potentiated and light-enhanced startle paradigms in the rat

Michel A. Steiner, Hugues Lecourt, Ando Rakotoariniaina, Francois Jenck

Journal:

Behavioural Brain Research

Year:

2011

Language:

english

File:

PDF, 643 KB

english, 2011

44

Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats

François Jenck, Jean-Luc Moreau, Hemmie H.G Berendsen, Michael Boes, Chris L.E Broekkamp, James R Martin, Jürgen Wichmann, Anton M.L Van Delft

Journal:

European Neuropsychopharmacology

Year:

1998

Language:

english

File:

PDF, 101 KB

english, 1998

45

Examining the role of endogenous orexins in hypothalamus–pituitary–adrenal axis endocrine function using transient dual orexin receptor antagonism in the rat

Steiner, Michel A., Sciarretta, Carla, Brisbare-Roch, Catherine, Strasser, Daniel S., Studer, Rolf, Jenck, Francois

Journal:

Psychoneuroendocrinology

Year:

2013

Language:

english

File:

PDF, 603 KB

english, 2013

46

Differential Effects of the Dual Orexin Receptor Antagonist Almorexant and the GABAA-α1 Receptor Modulator Zolpidem, Alone or Combined with Ethanol, on Motor Performance in the Rat

Steiner, Michel A, Lecourt, Hugues, Strasser, Daniel S, Brisbare-Roch, Catherine, Jenck, François

Journal:

Neuropsychopharmacology

Year:

2011

Language:

english

File:

PDF, 774 KB

english, 2011

47

From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in Dogs

Brotschi, Christine, Bolli, Martin H., Gatfield, John, Heidmann, Bibia, Jenck, Francois, Roch, Catherine, Sifferlen, Thierry, Treiber, Alexander, Williams, Jodi T., Boss, Christoph

Journal:

Year:

2020

Language:

english

File:

PDF, 3.34 MB

english, 2020

48

Evaluation of the dependence liability of quinolizinones acting as partial agonists at the benzodiazepine receptor

Dr. James R. Martin, Jean-Luc Moreau, François Jenck

Journal:

Drug Development Research

Year:

1995

Language:

english

File:

PDF, 808 KB

english, 1995

49

Physical dependence Induced In DBA/2J mice by benzodiazeplne receptor full agonists, but not by the partial agonist Ro 16-6028

Jean-Luc Moreau, François Jenck, Lorenzo Pieri, Peter Schoch, James R. Martin, Willy E. Haefely

Journal:

European Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 563 KB

english, 1990

50

Orphanin FQ Acts as an Anxiolytic to Attenuate Behavioral Responses to Stress

Francois Jenck, Jean-Luc Moreau, James R. Martin, Gavin J. Kilpatrick, Rainer K. Reinscheid, Frederick J. Monsma, Hans-Peter Nothacker and Olivier Civelli

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 850 KB

english, 1997

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